A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy

Chao Cheng Chen, Ju Yu Chen, Hui Wen Chan, Deng Yuan Chang, Hsin Ell Wang, Liang Ting Lin

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Gold nanoparticles attract great attention in potential theranostics options for aggressive triple-negative breast cancer (TNBC), by sensitizing tumor to non-invasive photothermal therapy (PTT) and enabling multifunctional imaging, with an enhanced efficacy and reduced systemic cytotoxicity. Gold nanostars possess tremendous benefits among gold nanostructures, due to the distinct absorption peak in near-infrared region and excellent photothermal conversion efficiency. The surface plasmon resonance of nanostars enables photoacoustic imaging (PAI) by an efficient conversion of photons to photoacoustic signals. In this study, we investigated the PEGylated gold nanostars (pAuNSs) uptake in orthotopic TNBC tumor with PAI and radionuclide-based biodistribution. A prominent pAuNSs uptake in tumor was found steadily within 2-24 h after intravenous injection by both methods. The tumor was exposed to laser (808 nm, 1 W/cm2) for 3 min twice at 24 h post-intravenous injection. The photothermal effect of pAuNSs induced a rise in tumor temperature to 55 ℃, which could kill tumor tissue by thermal ablation. The tumor in pAuNSs-mediated laser group was markedly shrunken up to day 21 post-treatment, also reflected by the reduction of luciferase activity in bioluminescent imaging. Overall, this work presented a novel nanoplatform for PAI-guided PTT mediated by pAuNSs and revealed effective thermal ablation in eliminating TNBC tumor.

Original languageEnglish
Title of host publicationFuture Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020
EditorsKang-Ping Lin, Ren-Shyan Liu, Bang-Hung Yang
PublisherSpringer Science and Business Media Deutschland GmbH
Pages17-25
Number of pages9
ISBN (Print)9783030927851
DOIs
Publication statusPublished - 2022
EventInternational conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020 - Taipei, Taiwan
Duration: 20 Nov 202022 Nov 2020

Publication series

NameSpringer Proceedings in Physics
Volume272
ISSN (Print)0930-8989
ISSN (Electronic)1867-4941

Conference

ConferenceInternational conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020
Country/TerritoryTaiwan
CityTaipei
Period20/11/2022/11/20

Keywords

  • Biodistribution
  • Gold nanoparticles
  • Photoacoustic imaging
  • Photothermal therapy
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • General Physics and Astronomy

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