@inproceedings{dd753f2859ae4e7e96210e571ba220dd,
title = "A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy",
abstract = "Gold nanoparticles attract great attention in potential theranostics options for aggressive triple-negative breast cancer (TNBC), by sensitizing tumor to non-invasive photothermal therapy (PTT) and enabling multifunctional imaging, with an enhanced efficacy and reduced systemic cytotoxicity. Gold nanostars possess tremendous benefits among gold nanostructures, due to the distinct absorption peak in near-infrared region and excellent photothermal conversion efficiency. The surface plasmon resonance of nanostars enables photoacoustic imaging (PAI) by an efficient conversion of photons to photoacoustic signals. In this study, we investigated the PEGylated gold nanostars (pAuNSs) uptake in orthotopic TNBC tumor with PAI and radionuclide-based biodistribution. A prominent pAuNSs uptake in tumor was found steadily within 2-24 h after intravenous injection by both methods. The tumor was exposed to laser (808 nm, 1 W/cm2) for 3 min twice at 24 h post-intravenous injection. The photothermal effect of pAuNSs induced a rise in tumor temperature to 55 ℃, which could kill tumor tissue by thermal ablation. The tumor in pAuNSs-mediated laser group was markedly shrunken up to day 21 post-treatment, also reflected by the reduction of luciferase activity in bioluminescent imaging. Overall, this work presented a novel nanoplatform for PAI-guided PTT mediated by pAuNSs and revealed effective thermal ablation in eliminating TNBC tumor.",
keywords = "Biodistribution, Gold nanoparticles, Photoacoustic imaging, Photothermal therapy, Triple-negative breast cancer",
author = "Chen, {Chao Cheng} and Chen, {Ju Yu} and Chan, {Hui Wen} and Chang, {Deng Yuan} and Wang, {Hsin Ell} and Lin, {Liang Ting}",
note = "Funding Information: Acknowledgements This work is supported by Early Career Scheme (25103719) by the Research Grant Council, HKSAR. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.; International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020 ; Conference date: 20-11-2020 Through 22-11-2020",
year = "2022",
doi = "10.1007/978-3-030-92786-8_3",
language = "English",
isbn = "9783030927851",
series = "Springer Proceedings in Physics",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "17--25",
editor = "Kang-Ping Lin and Ren-Shyan Liu and Bang-Hung Yang",
booktitle = "Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020",
address = "Germany",
}