A chemical probe for lysine malonylation

Xiucong Bao, Qian Zhao, Tangpo Yang, Yi Man Eva Fung, Xiang David Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

47 Citations (Scopus)

Abstract

Tag! You′re it! MalAM-yne is a chemical reporter for malonylation of lysines within proteins (see scheme), a newly identified posttranslational modification. MalAM-yne is cell-permeable and metabolically incorporated into proteins in living cells. Subsequent bioorthogonal tag conjugation allows the fluorescent visualization of cellular malonylation and profiling of malonylated proteins.
Original languageEnglish
Pages (from-to)4883-4886
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number18
DOIs
Publication statusPublished - 26 Apr 2013
Externally publishedYes

Keywords

  • click chemistry
  • lysine malonylation
  • metabolic labeling
  • posttranslational modifications
  • protein modifications

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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