A case report of hepatitis B related optic neuritis treated with plasma exchange

Da Teng, Shaoying Tan, Mo Yang, Junqing Wang, Jie Zhao, Quangang Xu, Shihui Wei

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)


Introduction:There are few studies focusing on Binocular hepatitis B related optic neuritis (HB-ON) and associated therapies are still limited. We present a case of HB-ON which has been cured with therapeutic plasma exchange (TPE).Patient concerns:The patient was diagnosed as acute hepatitis B in hepatology and got a rapid loss of binocular visual acuity (2/100 in the right eye and no light perception in the left eye) after the onset.Diagnosis:Hepatitis B related optic neuritis.Interventions:Methylprednisolone and therapeutic plasma exchange.Outcomes:The treatment of high dose methylprednisolone was not curative. After 5 TPE sessions, the patient's best corrected visual acuity (BCVA) returned to 20/20 in the right eye and finger counting (FC)/40cm in the left eye. One month later, the visual acuity increased to 5/100 in the left eye.Conclusion:This is the first case in which we used TPE to cure HB-ON. Also, it can demonstrate the relationship between HB-ON and immunopathogenesis. The case may provide an effective method for the treatment of hormone invalid and disabled ON in clinical practice.

Original languageEnglish
Article numbere15432
JournalMedicine (United States)
Issue number18
Publication statusPublished - 1 May 2019
Externally publishedYes


  • extrahepatic diseases
  • hepatitis B
  • optic neuritis
  • plasma exchange

ASJC Scopus subject areas

  • General Medicine


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