A bioengineered arginine-depleting enzyme as a long-lasting therapeutic agent against cancer

Keyphrases

• Bioengineering 100%
• Therapeutic Agents 100%
• Arginine 100%
• Human Arginase I 100%
• I-mutant 94%
• Cancer Cell Lines 11%
• Cancer Therapy 11%
• Cancer Types 11%
• Catalytic Efficiency 11%
• L-Arg 11%
• Heavy Metals 5%
• In Cancer 5%
• Enzyme Activity 5%
• In Vitro Study 5%
• Clinical Trials 5%
• Ni2+ 5%
• Mn2+ 5%
• Arginine Deiminase 5%
• PEGylated 5%
• Immunogenicity 5%
• Circular Dichroism Spectroscopy 5%
• PEGylation 5%
• After Injection 5%
• Enzyme Kinetics 5%
• Kcat 5%
• Protein Secondary Structure 5%
• Efficiency Trends 5%
• Mono-PEGylation 5%
• Catalytic Metal Ions 5%
• Homogeneous Products 5%
• PEG-maleimide 5%
• Pharmacodynamic Study 5%
• Branched PEG 5%
• Limit of Detection 5%
• Return to Normal 5%
• Co2+ 5%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Arginase 100%
• Arginine 100%
• Catalytic Efficiency 11%
• Cancer Cell 11%
• PEGylation 11%
• Wild Type 5%
• Protein Secondary Structure 5%
• Clinical Trial 5%
• Cofactors 5%
• In Vitro Study 5%
• Turnover Number 5%
• Enzyme Kinetics 5%
• Pharmacodynamics 5%
• Enzyme Activity 5%
• Body Weight 5%
• Immunogenicity 5%
• Circular Dichroism 5%
• Arginine Deiminase 5%