A Biocompatible Vibration-Actuated Omni-Droplets Rectifier with Large Volume Range Fabricated by Femtosecond Laser

Yiyuan Zhang, Jing Li, Le Xiang, Jinxing Wang, Tao Wu, Yunlong Jiao, Shaojun Jiang, Chuanzong Li, Shengying Fan, Juan Zhang, Hao Wu, Yuxuan Zhang, Yucheng Bian, Kun Zhao, Yubin Peng, Wulin Zhu, Jiawen Li, Yanlei Hu, Dong Wu, Jiaru ChuZuankai Wang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

15 Citations (Scopus)


High-performance droplet transport is crucial for diverse applications including biomedical detection, chemical micro-reaction, and droplet microfluidics. Despite extensive progress, traditional passive and active strategies are restricted to limited liquid types, small droplet volume ranges, and poor biocompatibilities. Moreover, more challenges occur for biological fluids due to large viscosity and low surface tension. Here, a vibration-actuated omni-droplets rectifier (VAODR) consisting of slippery ratchet arrays fabricated by femtosecond laser and vibration platforms is reported. Through the relative competition between the asymmetric adhesive resistance originating from the lubricant meniscus on the VAODR and the periodic inertial driving force originating from isotropic vibration, the fast (up to ≈60 mm s−1), programmable, and robust transport of droplets is achieved for a large volume range (0.05–2000 µL, Vmax/Vmin ≈ 40 000) and in various transport modes including transport of liquid slugs in tubes, programmable and sequential transport, and bidirectional transport. This VAODR is general to a high diversity of biological and medical fluids, and thus can be used for biomedical detection including ABO blood-group tests and anticancer drugs screening. These strategies provide a complementary and promising platform for maneuvering omni-droplets that are fundamental to biomedical applications and other high-throughput omni-droplet operation fields.

Original languageEnglish
Article number2108567
JournalAdvanced Materials
Issue number12
Publication statusPublished - 24 Mar 2022
Externally publishedYes


  • biomedical detection | biomedical devices
  • mechanical vibration
  • omni-droplets rectifiers
  • slippery ratchets

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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