TY - JOUR
T1 - A Biocompatible Vibration-Actuated Omni-Droplets Rectifier with Large Volume Range Fabricated by Femtosecond Laser
AU - Zhang, Yiyuan
AU - Li, Jing
AU - Xiang, Le
AU - Wang, Jinxing
AU - Wu, Tao
AU - Jiao, Yunlong
AU - Jiang, Shaojun
AU - Li, Chuanzong
AU - Fan, Shengying
AU - Zhang, Juan
AU - Wu, Hao
AU - Zhang, Yuxuan
AU - Bian, Yucheng
AU - Zhao, Kun
AU - Peng, Yubin
AU - Zhu, Wulin
AU - Li, Jiawen
AU - Hu, Yanlei
AU - Wu, Dong
AU - Chu, Jiaru
AU - Wang, Zuankai
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (nos. U20A20290, 61927814, 52122511, 91963127, 52075516, 51875544, 51805508), Hefei Natural Science Foundation (2021020), Fundamental Research Funds for the Central Universities (JZ2021HGTB0101), Major Scientific and Technological Projects in Anhui Province (201903a05020005), and Fundamental Research Funds for the Central Universities (YD2090002005, WK2090000024). The authors acknowledge the Experimental Center of Engineering and Material Sciences at USTC for the fabrication and measuring of samples. This work was partly carried out at the USTC Center for Micro and Nanoscale Research and Fabrication.
Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022/3/24
Y1 - 2022/3/24
N2 - High-performance droplet transport is crucial for diverse applications including biomedical detection, chemical micro-reaction, and droplet microfluidics. Despite extensive progress, traditional passive and active strategies are restricted to limited liquid types, small droplet volume ranges, and poor biocompatibilities. Moreover, more challenges occur for biological fluids due to large viscosity and low surface tension. Here, a vibration-actuated omni-droplets rectifier (VAODR) consisting of slippery ratchet arrays fabricated by femtosecond laser and vibration platforms is reported. Through the relative competition between the asymmetric adhesive resistance originating from the lubricant meniscus on the VAODR and the periodic inertial driving force originating from isotropic vibration, the fast (up to ≈60 mm s−1), programmable, and robust transport of droplets is achieved for a large volume range (0.05–2000 µL, Vmax/Vmin ≈ 40 000) and in various transport modes including transport of liquid slugs in tubes, programmable and sequential transport, and bidirectional transport. This VAODR is general to a high diversity of biological and medical fluids, and thus can be used for biomedical detection including ABO blood-group tests and anticancer drugs screening. These strategies provide a complementary and promising platform for maneuvering omni-droplets that are fundamental to biomedical applications and other high-throughput omni-droplet operation fields.
AB - High-performance droplet transport is crucial for diverse applications including biomedical detection, chemical micro-reaction, and droplet microfluidics. Despite extensive progress, traditional passive and active strategies are restricted to limited liquid types, small droplet volume ranges, and poor biocompatibilities. Moreover, more challenges occur for biological fluids due to large viscosity and low surface tension. Here, a vibration-actuated omni-droplets rectifier (VAODR) consisting of slippery ratchet arrays fabricated by femtosecond laser and vibration platforms is reported. Through the relative competition between the asymmetric adhesive resistance originating from the lubricant meniscus on the VAODR and the periodic inertial driving force originating from isotropic vibration, the fast (up to ≈60 mm s−1), programmable, and robust transport of droplets is achieved for a large volume range (0.05–2000 µL, Vmax/Vmin ≈ 40 000) and in various transport modes including transport of liquid slugs in tubes, programmable and sequential transport, and bidirectional transport. This VAODR is general to a high diversity of biological and medical fluids, and thus can be used for biomedical detection including ABO blood-group tests and anticancer drugs screening. These strategies provide a complementary and promising platform for maneuvering omni-droplets that are fundamental to biomedical applications and other high-throughput omni-droplet operation fields.
KW - biomedical detection | biomedical devices
KW - mechanical vibration
KW - omni-droplets rectifiers
KW - slippery ratchets
UR - http://www.scopus.com/inward/record.url?scp=85124503533&partnerID=8YFLogxK
U2 - 10.1002/adma.202108567
DO - 10.1002/adma.202108567
M3 - Journal article
C2 - 34865264
AN - SCOPUS:85124503533
VL - 34
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 12
M1 - 2108567
ER -