@article{512811c315be4f6597e27eb29ff10745,
title = "A biocompatible photosensitizer with a high intersystem crossing efficiency for precise two-photon photodynamic therapy",
abstract = "Photodynamic efficiency is strongly dependent on the generation rate of reactive oxygen species (ROS) and the tissue penetration depth. Recent advances in materials science reveal that organic molecules with room-temperature phosphorescence (RTP) can potentially serve as efficient photosensitizers owing to their limited dark cytotoxicity and abundant triplet excitons upon light irradiation. In this study, we combine RTP materials with two-photon excitation to improve the ROS generation, therapeutic precision, and tissue penetration of photodynamic therapy. We successfully prepared a novel RTP-based photosensitizer (BF2DCz) with a high photoluminescence quantum yield of 47.7 ± 3% and a remarkable intersystem crossing efficiency of ∼90.3%. By encapsulation into the bovine serum albumin (BSA) matrix, BF2DCz-BSA exhibits excellent biocompatibility, negligible dark toxicity, and superior photostability. Excitation using a femtosecond laser causes BF2DCz-BSA to efficiently generate ROS and precisely exert cell damage at the desired location.",
author = "Zhourui Xu and Yihang Jiang and Yuanyuan Shen and Lele Tang and Zulu Hu and Guimiao Lin and Law, {Wing Cheung} and Mingze Ma and Biqin Dong and Yong, {Ken Tye} and Gaixia Xu and Ye Tao and Runfeng Chen and Chengbin Yang",
note = "Funding Information: This work was financially supported by the National Natural Science Foundation of China (81801859, 31871442, 12074269, 22075149 and 61875090), the Natural Science Foundation of Guangdong Province (2019A1515012163 and 2021A1515012159), the Guangdong Medical Science and Technology Research Funding (A2019359), the University Stable Support Research Funding of Shenzhen (20200813153346001), the Research Grants Council of the Hong Kong Special Administrative Region, China (PolyU 15208720), the Basic Research Foundation of Shenzhen (JCYJ20180305125254860), the “Jiangsu Specially-Appointed Professor Plan”, the Six Talent Plan of Jiangsu Province (XCL-049), and a Start-up Grant from Shenzhen University (2019136). The authors greatly appreciate the help from the Instrumental Analysis Center of Shenzhen University for the assistance with imaging analysis. The animal experiment is in accordance with the regulations of the Animal Ethical and Welfare Committee of Shenzhen University (AEWC-SZU). Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",
year = "2022",
month = feb,
day = "3",
doi = "10.1039/d1mh01869h",
language = "English",
volume = "9",
pages = "1283--1292",
journal = "Materials Horizons",
issn = "2051-6347",
publisher = "Royal Society of Chemistry",
number = "4",
}