A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm

Xin Liu; Yuming Sun; Yuanhong Zhang; Fang Miao; Guancong Wang; Hongshi Zhao; Xiaoqiang Yu; Hong Liu; Wai Yeung Wong

doi:10.1039/c1ob05123g

A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm

Xin Liu, Yuming Sun, Yuanhong Zhang, Fang Miao, Guancong Wang, Hongshi Zhao, Xiaoqiang Yu, Hong Liu, Wai Yeung Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

75 Citations (Scopus)

Abstract

A new carbazole-derived dicationic compound, namely 2,7-bis(1-hydroxyethyl- 4-vinylpyridinium iodine)-N-ethylcarbazole (2,7-9E-BHVC), with a large two-photon action absorption cross section in nucleic acids has been obtained. Moreover, it possesses the potential of imaging RNA in nucleoli and cytoplasm in two-photon fluorescence microscopy and exhibits good counterstain compatibility with the commercial fluorescent nucleic dye DAPI.

Original language	English
Pages (from-to)	3615-3618
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	10
DOIs	https://doi.org/10.1039/c1ob05123g
Publication status	Published - 21 May 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c1ob05123g

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abstract = "A new carbazole-derived dicationic compound, namely 2,7-bis(1-hydroxyethyl- 4-vinylpyridinium iodine)-N-ethylcarbazole (2,7-9E-BHVC), with a large two-photon action absorption cross section in nucleic acids has been obtained. Moreover, it possesses the potential of imaging RNA in nucleoli and cytoplasm in two-photon fluorescence microscopy and exhibits good counterstain compatibility with the commercial fluorescent nucleic dye DAPI.",

author = "Xin Liu and Yuming Sun and Yuanhong Zhang and Fang Miao and Guancong Wang and Hongshi Zhao and Xiaoqiang Yu and Hong Liu and Wong, {Wai Yeung}",

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language = "English",

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A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm. / Liu, Xin; Sun, Yuming; Zhang, Yuanhong et al.
In: Organic and Biomolecular Chemistry, Vol. 9, No. 10, 21.05.2011, p. 3615-3618.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm

AU - Liu, Xin

AU - Sun, Yuming

AU - Zhang, Yuanhong

AU - Miao, Fang

AU - Wang, Guancong

AU - Zhao, Hongshi

AU - Yu, Xiaoqiang

AU - Liu, Hong

AU - Wong, Wai Yeung

PY - 2011/5/21

Y1 - 2011/5/21

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AB - A new carbazole-derived dicationic compound, namely 2,7-bis(1-hydroxyethyl- 4-vinylpyridinium iodine)-N-ethylcarbazole (2,7-9E-BHVC), with a large two-photon action absorption cross section in nucleic acids has been obtained. Moreover, it possesses the potential of imaging RNA in nucleoli and cytoplasm in two-photon fluorescence microscopy and exhibits good counterstain compatibility with the commercial fluorescent nucleic dye DAPI.

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U2 - 10.1039/c1ob05123g

DO - 10.1039/c1ob05123g

M3 - Journal article

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SN - 1477-0520

VL - 9

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EP - 3618

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

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A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm

Abstract

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