3D printed fiber-optic nanomechanical bioprobe

Mengqiang Zou; Changrui Liao; Yanping Chen; Lei Xu; Shuo Tang; Gaixia Xu; Ke Ma; Jiangtao Zhou; Zhihao Cai; Bozhe Li; Cong Zhao; Zhourui Xu; Yuanyuan Shen; Shen Liu; Ying Wang; Zongsong Gan; Hao Wang; Xuming Zhang; Sandor Kasas; Yiping Wang

doi:10.1088/2631-7990/acb741

3D printed fiber-optic nanomechanical bioprobe

Mengqiang Zou, Changrui Liao (Corresponding Author), Yanping Chen, Lei Xu, Shuo Tang, Gaixia Xu, Ke Ma, Jiangtao Zhou, Zhihao Cai, Bozhe Li, Cong Zhao, Zhourui Xu, Yuanyuan Shen, Shen Liu, Ying Wang, Zongsong Gan, Hao Wang, Xuming Zhang, Sandor Kasas, Yiping Wang (Corresponding Author)

Research output: Journal article publication › Journal article › Academic research › peer-review

26 Citations (Scopus)

Abstract

Highlights Some highlights of this manuscript are listed as follow: A miniature fiber optical nanomechanical probe (FONP) can be used to detect the mechanical properties of single cells and in vivo tissue measurements is demonstrated. The FONP is developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser 3D printing. A strategy of customizing the microcantilever’s spring constant according to the sample based on structure-correlated mechanics is proposed and the stiffness of FONP is adjustable. The FONPs can operate in air/liquids and show ultra-high force resolution, whose highest microforce sensitivity and detection limit are 54.5 nm μN ⁻¹, 2.1 nN respectively.

Original language	English
Article number	015005
Pages (from-to)	1-14
Number of pages	14
Journal	International Journal of Extreme Manufacturing
Volume	5
Issue number	1
DOIs	https://doi.org/10.1088/2631-7990/acb741
Publication status	Published - Mar 2023

Keywords

biosensor
nanomechanical probe
optical fiber sensor
stiffness tunable microcantilever
two-photon polymerization nanolithography

ASJC Scopus subject areas

Industrial and Manufacturing Engineering

More information

10.1088/2631-7990/acb741

http://hdl.handle.net/10397/105905

Cite this

@article{cc28b58fda35416eaf506d6b45f9e70b,

title = "3D printed fiber-optic nanomechanical bioprobe",

abstract = "Highlights Some highlights of this manuscript are listed as follow: A miniature fiber optical nanomechanical probe (FONP) can be used to detect the mechanical properties of single cells and in vivo tissue measurements is demonstrated. The FONP is developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser 3D printing. A strategy of customizing the microcantilever{\textquoteright}s spring constant according to the sample based on structure-correlated mechanics is proposed and the stiffness of FONP is adjustable. The FONPs can operate in air/liquids and show ultra-high force resolution, whose highest microforce sensitivity and detection limit are 54.5 nm μN −1, 2.1 nN respectively.",

keywords = "biosensor, nanomechanical probe, optical fiber sensor, stiffness tunable microcantilever, two-photon polymerization nanolithography",

author = "Mengqiang Zou and Changrui Liao and Yanping Chen and Lei Xu and Shuo Tang and Gaixia Xu and Ke Ma and Jiangtao Zhou and Zhihao Cai and Bozhe Li and Cong Zhao and Zhourui Xu and Yuanyuan Shen and Shen Liu and Ying Wang and Zongsong Gan and Hao Wang and Xuming Zhang and Sandor Kasas and Yiping Wang",

note = "Funding Information: This study was supported by the National Natural Science Foundation of China (NSFC) (62122057, 62075136, 62175165); Natural Science Foundation of Guangdong Province (2022B1515120061, 2019B1515120042); Science and Technology Innovation Commission of Shenzhen (RCYX20200714114524139, JCYJ20200109114001806). Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by IOP Publishing Ltd on behalf of the IMMT.",

year = "2023",

month = mar,

doi = "10.1088/2631-7990/acb741",

language = "English",

volume = "5",

pages = "1--14",

journal = "International Journal of Extreme Manufacturing",

issn = "2631-8644",

publisher = "IOP Publishing Ltd.",

number = "1",

}

TY - JOUR

T1 - 3D printed fiber-optic nanomechanical bioprobe

AU - Zou, Mengqiang

AU - Liao, Changrui

AU - Chen, Yanping

AU - Xu, Lei

AU - Tang, Shuo

AU - Xu, Gaixia

AU - Ma, Ke

AU - Zhou, Jiangtao

AU - Cai, Zhihao

AU - Li, Bozhe

AU - Zhao, Cong

AU - Xu, Zhourui

AU - Shen, Yuanyuan

AU - Liu, Shen

AU - Wang, Ying

AU - Gan, Zongsong

AU - Wang, Hao

AU - Zhang, Xuming

AU - Kasas, Sandor

AU - Wang, Yiping

N1 - Funding Information: This study was supported by the National Natural Science Foundation of China (NSFC) (62122057, 62075136, 62175165); Natural Science Foundation of Guangdong Province (2022B1515120061, 2019B1515120042); Science and Technology Innovation Commission of Shenzhen (RCYX20200714114524139, JCYJ20200109114001806). Publisher Copyright: © 2023 The Author(s). Published by IOP Publishing Ltd on behalf of the IMMT.

PY - 2023/3

Y1 - 2023/3

N2 - Highlights Some highlights of this manuscript are listed as follow: A miniature fiber optical nanomechanical probe (FONP) can be used to detect the mechanical properties of single cells and in vivo tissue measurements is demonstrated. The FONP is developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser 3D printing. A strategy of customizing the microcantilever’s spring constant according to the sample based on structure-correlated mechanics is proposed and the stiffness of FONP is adjustable. The FONPs can operate in air/liquids and show ultra-high force resolution, whose highest microforce sensitivity and detection limit are 54.5 nm μN −1, 2.1 nN respectively.

AB - Highlights Some highlights of this manuscript are listed as follow: A miniature fiber optical nanomechanical probe (FONP) can be used to detect the mechanical properties of single cells and in vivo tissue measurements is demonstrated. The FONP is developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser 3D printing. A strategy of customizing the microcantilever’s spring constant according to the sample based on structure-correlated mechanics is proposed and the stiffness of FONP is adjustable. The FONPs can operate in air/liquids and show ultra-high force resolution, whose highest microforce sensitivity and detection limit are 54.5 nm μN −1, 2.1 nN respectively.

KW - biosensor

KW - nanomechanical probe

KW - optical fiber sensor

KW - stiffness tunable microcantilever

KW - two-photon polymerization nanolithography

UR - http://www.scopus.com/inward/record.url?scp=85148210836&partnerID=8YFLogxK

U2 - 10.1088/2631-7990/acb741

DO - 10.1088/2631-7990/acb741

M3 - Journal article

SN - 2631-8644

VL - 5

SP - 1

EP - 14

JO - International Journal of Extreme Manufacturing

JF - International Journal of Extreme Manufacturing

IS - 1

M1 - 015005

ER -

3D printed fiber-optic nanomechanical bioprobe

Abstract

Keywords

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this