3D graphene/hydroxypropyl-β-cyclodextrin nanocomposite as an electrochemical chiral sensor for the recognition of tryptophan enantiomers

Wenting Liang, Yanqin Rong, Lifang Fan, Wenjuan Dong, Qingchen Dong, Cheng Yang, Zhihui Zhong, Chuan Dong, Shaomin Shuang, Wai Yeung Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

45 Citations (Scopus)

Abstract

A novel and facile chiral sensing platform has been designed for electrochemical enantiomer recognition based on the coupling of three-dimensional-graphene with hydroxypropyl-β-cyclodextrin (3D-G/HP-β-CD). The chiral platform synergistically exploits HP-β-CD as a supramolecular chiral recognizer and 3D-G as an electrochemical indicator, to recognize tryptophan (Trp) enantiomers by differential pulse voltammetry (DPV) approach with significantly discernable electrochemical signals. The different host-guest interactions of d- and l-Trp with HP-β-CD reveal high binding affinity to target l-tryptophan for sensing tryptophan isomers. Moreover, we found that the peak currents of the two enantiomers showed a linear response in the concentration range of 0.5-175 μM with low detection limits of 9.6 nM and 38 nM for l- and d-Trp (S/N = 3), respectively, exhibiting remarkable sensitivity, fine reproducibility as well as great stability. This process, which is the initial demonstration of cyclodextrin-functionalized 3D-G for an electrochemical chiral recognition application, provides a new strategy for enantiosensing.

Original languageEnglish
Pages (from-to)12822-12829
Number of pages8
JournalJournal of Materials Chemistry C
Volume6
Issue number47
DOIs
Publication statusPublished - 1 Jan 2018

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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