3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

Zhijie Huan; Kar Hang Chu; Jie Yang; Dong Sun

doi:10.1109/ICInfA.2015.7279556

3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

Zhijie Huan, Kar Hang Chu, Jie Yang, Dong Sun

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

3 Citations (Scopus)

Abstract

Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.

Original language	English
Title of host publication	2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics
Publisher	IEEE
Pages	1680-1685
Number of pages	6
ISBN (Electronic)	9781467391047
DOIs	https://doi.org/10.1109/ICInfA.2015.7279556
Publication status	Published - 28 Sep 2015
Externally published	Yes
Event	2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics - Yunnan, China Duration: 8 Aug 2015 → 10 Aug 2015

Conference

Conference	2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics
Country	China
City	Yunnan
Period	8/08/15 → 10/08/15

Keywords

Bones
Computer architecture
Dielectrophoresis
Electric fields
Force
Microprocessors
Three-dimensional displays

ASJC Scopus subject areas

Computer Networks and Communications
Human-Computer Interaction
Computational Theory and Mathematics
Control and Systems Engineering
Computer Vision and Pattern Recognition
Computer Science Applications

More information

10.1109/ICInfA.2015.7279556

Cite this

Huan, Z., Chu, K. H., Yang, J., & Sun, D. (2015). 3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues. In 2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics (pp. 1680-1685). [7279556] IEEE. https://doi.org/10.1109/ICInfA.2015.7279556

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title = "3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues",

abstract = "Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.",

keywords = "Bones, Computer architecture, Dielectrophoresis, Electric fields, Force, Microprocessors, Three-dimensional displays",

author = "Zhijie Huan and Chu, {Kar Hang} and Jie Yang and Dong Sun",

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doi = "10.1109/ICInfA.2015.7279556",

language = "English",

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booktitle = "2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics",

publisher = "IEEE",

address = "United States",

note = "2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics ; Conference date: 08-08-2015 Through 10-08-2015",

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Huan, Z, Chu, KH, Yang, J & Sun, D 2015, 3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues. in 2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics., 7279556, IEEE, pp. 1680-1685, 2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics, Yunnan, China, 8/08/15. https://doi.org/10.1109/ICInfA.2015.7279556

3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues. / Huan, Zhijie; Chu, Kar Hang; Yang, Jie; Sun, Dong.

2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics. IEEE, 2015. p. 1680-1685 7279556.

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

TY - GEN

T1 - 3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

AU - Huan, Zhijie

AU - Chu, Kar Hang

AU - Yang, Jie

AU - Sun, Dong

PY - 2015/9/28

Y1 - 2015/9/28

N2 - Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.

AB - Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.

KW - Bones

KW - Computer architecture

KW - Dielectrophoresis

KW - Electric fields

KW - Force

KW - Microprocessors

KW - Three-dimensional displays

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BT - 2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics

PB - IEEE

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3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

Abstract

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Keywords

ASJC Scopus subject areas

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