3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

Zhijie Huan, Kar Hang Chu, Jie Yang, Dong Sun

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

3 Citations (Scopus)

Abstract

Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.
Original languageEnglish
Title of host publication2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics
PublisherIEEE
Pages1680-1685
Number of pages6
ISBN (Electronic)9781467391047
DOIs
Publication statusPublished - 28 Sep 2015
Externally publishedYes
Event2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics - Yunnan, China
Duration: 8 Aug 201510 Aug 2015

Conference

Conference2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics
CountryChina
CityYunnan
Period8/08/1510/08/15

Keywords

  • Bones
  • Computer architecture
  • Dielectrophoresis
  • Electric fields
  • Force
  • Microprocessors
  • Three-dimensional displays

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Human-Computer Interaction
  • Computational Theory and Mathematics
  • Control and Systems Engineering
  • Computer Vision and Pattern Recognition
  • Computer Science Applications

Cite this