αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou; Chi Fai Chan; Daniel W.J. Kwong; Ga Lai Law; Steven Cobb; Wai Kwok Wong; Ka Leung Wong

doi:10.1039/c6cc09246b

α_vβ₃-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou, Chi Fai Chan, Daniel W.J. Kwong, Ga Lai Law, Steven Cobb, Wai Kwok Wong, Ka Leung Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

26 Citations (Scopus)

Abstract

We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3isoform overexpressed on the cell membrane.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	3
DOIs	https://doi.org/10.1039/c6cc09246b
Publication status	Published - 1 Jan 2017

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1039/c6cc09246b

http://hdl.handle.net/10397/64525

Cite this

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title = "αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy",

abstract = "We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3isoform overexpressed on the cell membrane.",

author = "Yan Zhou and Chan, {Chi Fai} and Kwong, {Daniel W.J.} and Law, {Ga Lai} and Steven Cobb and Wong, {Wai Kwok} and Wong, {Ka Leung}",

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AU - Zhou, Yan

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AU - Kwong, Daniel W.J.

AU - Law, Ga Lai

AU - Cobb, Steven

AU - Wong, Wai Kwok

AU - Wong, Ka Leung

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AB - We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3isoform overexpressed on the cell membrane.

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