Personal profile
Biography
Dr. Tan received the Bachelor degree in Mechanical Engineering from University of Science and Technology of China in 2005 and his PhD degree in Biomedical Engineering from both City University of Hong Kong and University of Science and Technology of China in 2010. He completed his postdoctoral fellowship in University of Illinois at Urbana-Champaign from 2011-2015. Since July 2015, Dr. Tan joined the Department of Biomedical Engineering at PolyU as Assistant Professor. Dr. Tan’s research interest includes cell mechanics and mechanobiology, especially the fundamental roles of mechanical forces in tumor metastasis. His research has been supported by many external grants, including 2 Hong Kong Research Grant Council General Research Fund (GRF), 1 Hong Kong Research Grant Council Collaborative Research Fund (CRF; Co-PI), 2 National Natural Science Foundation of China General Programme (NSFC), and 2 Shenzhen Science and Technology Innovation Commission Basic Research (STIC).
Research interests
Mechanobiology; Mechano-oncology; Tumour Metastasis; Cell Mechanics; Cancer Stem Cell.
Education/Academic qualification
Doctor of Philosophy, City University of Hong Kong
Bachelor of Engineering, University of Science and Technology of China
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Research output
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Hybrid EMT Phenotype and Cell Membrane Tension Promote Colorectal Cancer Resistance to Ferroptosis
Wei, X., Ge, Y., Zheng, Y., Zhao, S., Zhou, Y., Chang, Y., Wang, N., Wang, X., Zhang, J., Zhang, X., Hu, L., Tan, Y. & Jia, Q., 22 Feb 2025, In: Advanced Science. 12, 15, 2413882.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access12 Link opens in a new tab Citations (Scopus) -
Intercellular contractile force attenuates chemosensitivity through Notch-MVP-mediated nuclear drug export
Du, P., Tang, K., Chen, X., Xin, Y., Hu, B., Meng, J., Hu, G., Zhang, C., Li, K. & Tan, Y., 7 May 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 19, e2417626122.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity
Tang, K., Zheng, Y., Hu, G., Xin, Y., Li, K., Zhang, C., Chen, X., Zhang, B., Li, X., Hu, B., Jia, Q., Zheng, Y. P., Yang, M. & Tan, Y., 28 Feb 2025, In: Science advances. 11, 9, eadq2881.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access8 Link opens in a new tab Citations (Scopus) -
Stimulus-responsive gradient hydrogel microactuators fabricated by two-photon polymerization-based 4D printing
Li, T., Tsui, G. C. P. (Corresponding Author), Wong, C. H., Tang, C. Y., Tang, K. & Tan, Y., 1 Jan 2025, In: Nanotechnology Reviews. 14, 1, 15 p., 20250145.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Cell mechanics regulate the migration and invasion of hepatocellular carcinoma cells via JNK signaling
Wang, J., Zhang, B., Chen, X., Xin, Y., Li, K., Zhang, C., Tang, K. & Tan, Y., 1 Mar 2024, In: Acta Biomaterialia. 176, p. 321-333 13 p.Research output: Journal article publication › Journal article › Academic research › peer-review
10 Link opens in a new tab Citations (Scopus)
Prizes
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Best Paper Award in the 12th Chinese Biomechanics Conference
Tan, Y. (Recipient), 20 Aug 2018
Prize: Prize (research)
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Best Paper Award in the 6th International Conference on Biomedical Engineering and Biotechnology
Tan, Y. (Recipient), 20 Oct 2017
Prize: Prize (research)
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Activities
- 2 Editorial work for journals
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Biology (Journal)
Tan, Y. (Guest editor)
25 Feb 2020Activity: Publication peer-review and editorial work › Editorial work for journals
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PLoS ONE (Journal)
Tan, Y. (Editorial board member)
Jun 2019Activity: Publication peer-review and editorial work › Editorial work for journals
Press/Media
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Manipulation of the Nanoscale Presentation of Integrin Ligand Produces Cancer Cells with Enhanced Stemness and Robust Tumorigenicity
Wong, S. H. & Tan, Y.
4/12/21
1 item of Media coverage
Press/Media