• Yuk Choi Road, Hung Hom, Kowloon, Room ST507a, Core S, The Hong Kong Polytechnic University

    0000 Hong Kong

    Hong Kong

Calculated based on number of publications stored in Pure and citations from Scopus
20052020

Research activity per year

Personal profile

Biography

Dr Philip Ho completed Bachelor of Science in Biochemistry, and Master of Philosophy at the Hong Kong University of Science and Technology in 1997 and 1999, respectively. Afterward, Dr Ho obtained his Doctor of Philosophy degree in the Department of Medicine, University of Hong Kong in 2004. Before joining PolyU, Dr Ho received his postdoctoral fellowship and worked in a position as Research Assistant Professor and Scientific Officer in HKU.

Dr Ho’s research focuses on pre-clinical investigation of Parkinson’s disease and various related neurological disorders, including elucidation of the pathogenic mechanisms related to mitochondrial dysfunction and impaired autophagy associated with LRRK2 mutations using in vitro and in vivo experimental models to develop novel neuroprotective strategies. In addition to his in-house generated LRRK2 mutant mouse model, Dr Ho also started to develop PD patient-derived iPSCs as an alternative disease model. Moreover, Dr Ho is actively participating in collaborative research projects as principal investigator on environmental risks of chemicals of emerging concern in the State Key Laboratory of Marine Pollution (SKLMP, CityU). In particular, he has developed a novel human cell-based assay kit to assess level of estrogenicity induced by environmental xenoestrogens and various endocrine disruptive compounds. This novel assay has incorporated a novel patented protein tag as a major detection component of the assay kit. As a listed inventor, this invention is patented in US, Europe and China since 2015.

Dr Ho has published over 50 original research articles and invited reviews in prestigious peer-reviewed journals, including Autophagynpj Parkinson’s disease, and Translational Neurodegeneration. Philip obtained a number of competitive research grants, including HMRF and RGC/GRF as PI/Co-I, and supervised research postgraduate students in experimental neuroscience. Furthermore, he is invited as review editor, editorial board member, and ad hoc reviewer of a number of peer-reviewed journals, including Nature Communications, Translational Neurodegeneration, Journal of Neurology, Brain and Behavior, and Frontiers in Molecular Neuroscience, demonstrating his active participation in research community services.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Neuroscience, PhD, Pathophysiology of Parkinson's disease, The University of Hong Kong

Award Date: 1 Nov 2005

Keywords

  • RB Pathology
  • Parkinson's disease
  • Mitochondrial dysfunction
  • Autophagy
  • Mouse model
  • Environmental toxicology
  • Synucleinopathies

Fingerprint

Dive into the research topics where Wing Lok Ho is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or