Personal profile
Biography
Prof. Wing-Leung Wong received his Ph.D. degree in Organic Chemistry from the City University of Hong Kong in 2003. He has joined the Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, as a Research Assistant Professor since 2019. Currently, he is an Associate Professor of the Department. His research scopes include organic synthesis, catalysis, ionic liquids, biorecognition and molecular sensing, cell imaging, chemical biology and drug discovery.
Education/Academic qualification
Doctor of Philosophy, City University of Hong Kong
Bachelor of Science in Chemical Technology, The Hong Kong Polytechnic University
Keywords
- QD Chemistry
- RM Therapeutics. Pharmacology
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Collaborations and top research areas from the last five years
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A mitochondria-targeting and G-quadruplex structure-binding ligand inducing calcium overload and ferroptosis in human cancer cells
Zheng, B. X., Long, W., Zeng, Y. X., She, M. T., Zheng, Y., Zheng, W. D., Wang, Y. K., Chan, K. H., Leung, A. S. L., Chan, C. M., Lu, Y. J. & Wong, W. L., 9 May 2025, In: British Journal of Pharmacology. 182, 16, p. 3923-3951 29 p.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access8 Link opens in a new tab Citations (Scopus) -
Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy
Zheng, B. X., Long, W., Zheng, W., Zeng, Y., Guo, X. C., Chan, K. H., She, M. T., Leung, A. S. L., Lu, Y. J. & Wong, W. L., 16 Apr 2024, In: Journal of Medicinal Chemistry. 67, 8, p. 6292-6312 21 p.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access25 Link opens in a new tab Citations (Scopus) -
Targeting hTERT Promoter G-Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy
Long, W., Zeng, Y. X., Zheng, B. X., Li, Y. B., Wang, Y. K., Chan, K. H., She, M. T., Lu, Y. J., Cao, C. & Wong, W. L., 10 Jul 2024, In: Journal of Medicinal Chemistry. 67, 15, p. 13363-13382 20 p.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access29 Link opens in a new tab Citations (Scopus) -
Live Cell Imaging and Real-Time Monitoring of Nucleolus Morphology and Mitophagy with a Red Fluorescent and Photostable rRNA-Specific Probe in Human Cancer Cells
Luo, J. R., Long, W., Chen, Z. X., Wang, S. M., Zeng, Y. X., Lu, Y. J., Zheng, B. X., She, M. T. & Wong, W. L., 7 Mar 2024, In: ACS Sensors. 9, 3, p. 1545-1554 10 p.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access11 Link opens in a new tab Citations (Scopus) -
A NRAS mRNA G-quadruplex structure-targeting small-molecule ligand reactivating DNA damage response in human cancer cells for combination therapy with clinical PI3K inhibitors
Chan, K. H., Zheng, B. X., Leung, A. S. L., Long, W., Zhao, Y., Zheng, Y. & Wong, W. L., 6 Sept 2024, In: International Journal of Biological Macromolecules. 279, 135308.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus)
Prizes
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ABCT Excellence Award 2024 (Research Output) - Biology
Wong, W. L. (Recipient), Dec 2024
Prize: Prize (research)
Activities
- 3 Editorial work for journals
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Molecules (Journal)
Wong, W. L. (Guest editor)
Apr 2022 → …Activity: Publication peer-review and editorial work › Editorial work for journals
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Frontiers in Bioscience - Landmark (Journal)
Wong, W. L. (Guest editor)
25 Jun 2021 → …Activity: Publication peer-review and editorial work › Editorial work for journals
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Current Chinese Medical Science (Journal)
Wong, W. L. (Editorial board member)
2020 → 2021Activity: Publication peer-review and editorial work › Editorial work for journals