Personal profile
Biography
Dr. Thomas Lee received his bachelor, master, and doctoral degrees in chemical engineering from The Hong Kong University of Science and Technology in 1998, 2000, and 2003, respectively. He worked on PCR microchip and electrochemical DNA sensors under the supervision of Prof. I-Ming Hsing. In 2004, he joined Prof. Joseph Wang’s group in New Mexico State University and Arizona State University as a postdoc and worked on inorganic nanocrystals-based electrochemical sensor for single-base mismatches detection as well as aptamer-based electrochemical sensor for protein detection. In 2005, he returned to Prof. I-Ming Hsing’s group and worked on electrochemical real-time PCR. In 2006, he joined The Hong Kong Polytechnic University (PolyU) biomedical engineering program as an Assistant Professor. He is now an Associate Professor and his current research focus is on nucleic acid testing in point-of-care and field settings by means of novel colorimetric nanoprobes.
Research interests
Dr. Thomas Lee’s research focuses on the surface functionalization of nanomaterials (e.g., gold nanoparticles and quantum dots) for closed-tube monitoring of DNA amplification reactions (both isothermal and thermocycling methods). His research team aims to achieve point-of-care and on-site nucleic acid testing. He also works on nanomaterial-based enzyme mimetics (e.g., platinum nanoparticles supported on reduced graphene oxide with peroxidase-like activity) for colorimetric nucleic acid detection.
Education/Academic qualification
Bachelor of Engineering in Chemical Engineering, The Hong Kong University of Science and Technology
Master of Philosophy in Chemical Engineering, The Hong Kong University of Science and Technology
Doctor of Philosophy in Chemical Engineering, The Hong Kong University of Science and Technology
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Collaborations and top research areas from the last five years
Research output
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Gold Nanoparticle-Based Loop-Mediated Isothermal Amplification for Rapid, Low-Cost, and Simple Detection of Salmonella in Coffee and Cream
Wang, S., Lee, E. W. H., Yuen, J. Y. T., Woo, J. C. S., Wong, S., Chan, B. W. K., Yip, S. P. & Lee, M. H. T., 14 Jun 2025, Foodborne Pathogens: Loop-mediated Isothermal Amplification Protocols. Springer, p. 233-242Research output: Chapter in book / Conference proceeding › Chapter in an edited book (as author) › Academic research
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Visual Detection of Skin-Sensitizing Chemicals Using Gold Nanoparticles
Lan, H. & Lee, M. H. T., 21 May 2025.Research output: Unpublished conference presentation (presented paper, abstract, poster) › Poster › Academic research › peer-review
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Gold Nanoparticles and Quantum Dots as Loop-mediated Isothermal Amplification Result Readout Probes
Lee, M. H. T. (Inventor), Yip, S. P. (Inventor), Wang, S. (Inventor) & Qin, A. (Inventor), 9 Aug 2024Research output: Patents, agreements, assignments and companies › Licensing agreements
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Reverse transcription loop-mediated isothermal amplification assay for point-of-care molecular diagnosis of COVID-19 in the emergency department
Lee, M. H. T., Yip, S. P., Lam, R. P. K., Tsang, T. C. & Ranier, T., 19 Jun 2024.Research output: Unpublished conference presentation (presented paper, abstract, poster) › Conference presentation (not published in journal/proceeding/book) › Academic research › peer-review
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Amine-Functionalized Quantum Dots as a Universal Fluorescent Nanoprobe for a One-Step Loop-Mediated Isothermal Amplification Assay with Single-Copy Sensitivity
Wang, S., Qin, A., Chau, L. Y., Fok, E. W. T., Choy, M. Y., Brackman, C. J., Siu, G. K. H., Huang, C. L., Yip, S. P. & Lee, T. M. H., 10 Aug 2022, In: ACS applied materials & interfaces. 14, 31, p. 35299-35308 10 p.Research output: Journal article publication › Journal article › Academic research › peer-review
Open Access17 Link opens in a new tab Citations (Scopus)
Prizes
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Best Teacher Award, Interdisciplinary Division of Biomedical Engineering
Lee, M. H. T. (Recipient), 2016
Prize: Honorary award › Honorary award (teaching and learning)
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Faculty Award for Outstanding Achievement in Teaching (Individual)
Lee, M. H. T. (Recipient), 15 Jul 2022
Prize: Honorary award › Honorary award (teaching and learning)
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Faculty Merit Award in Teaching (Individual)
Lee, M. H. T. (Recipient), 2018
Prize: Honorary award › Honorary award (teaching and learning)
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Gold Medal - The 48th International Exhibition of Inventions of Geneva
Yip, S. P. (Recipient), Lee, M. H. T. (Recipient) & Wang, S. (Recipient), 28 Apr 2023
Prize: Prize (research)
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President's Award in Teaching
Lee, M. H. T. (Recipient), 2 Dec 2022
Prize: Honorary award › Honorary award (teaching and learning)
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EDC Workshop- Good Practices in Blended Learning: A Dialogue on How to Create Bonding among Students & Teachers
Tsui, Y. H. E. (Other), Tam, B. (Other), Hung, K. (Invited speaker), Ngai, S. B. C. (Invited speaker) & Lee, M. H. T. (Invited speaker)
25 Feb 2021Activity: Talk or presentation › Invited talk
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International Federation for Medical and Biological Engineering (Asia-Pacific Working Group) (External organisation)
Lee, M. H. T. (Member)
Sept 2018 → …Activity: Office holder / membership of professional bodies › Office holder / member of committee
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Hong Kong Institution of Engineers (HKIE) - Biomedical Division (External organisation)
Lee, M. H. T. (Other)
Mar 2018 → Sept 2019Activity: Office holder / membership of professional bodies › Office holder / member of committee
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Hong Kong Science and Technology Parks (Technology Business Incubation Programmes Admission Panel) (External organisation)
Lee, M. H. T. (Member)
Aug 2018 → Jul 2020Activity: Office holder / membership of professional bodies › Office holder / member of committee
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International Federation for Medical and Biological Engineering (Education & Accreditation Committee) (External organisation)
Lee, M. H. T. (Member)
Mar 2017 → …Activity: Office holder / membership of professional bodies › Office holder / member of committee