Virus N Gene Detection through Magnetic-Responsive SERS

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SERS (surface-enhanced Raman scattering) signals are promising for the detection of virus N genes. Prof Mo YANG, Associate Head and Professor of Biomedical Engineering, and Dr Siu Hong Dexter WONG, Research Assistant Professor of Biomedical Engineering, employed SERS for the detection of the N gene in SARs-CoV-2.

Together, the professors have developed a magnetic-responsive substrate consisting of heteoronanostructures, which controls the coupling distance for ultrasensitive and highly selective detection of the N gene of SARS-CoV-2.The platform magnetically modulates interparticle coupling for enhanced electric field strength and Raman signals.

The study proves the manipulation of DNA flexibility to control the coupling distance of metallic NPs by magnetic modulation. It also provides a promising strategy for detecting long-chain viral nucleic acids such as SARS-CoV-2 genes.

The department’s professors successfully published their findings in the international journal, ACS Applied Material Interfaces.

To learn more: https://pubs.acs.org/doi/10.1021/acsami.1c21173

Period4 Aug 2022

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1

Media coverage

  • TitleVirus N Gene Detection through Magnetic-Responsive SERS
    Degree of recognitionLocal
    Media name/outletVibrant@FENG eNewsletter PolyU
    Media typeWeb
    Country/TerritoryHong Kong
    Date4/08/22
    DescriptionSERS (surface-enhanced Raman scattering) signals are promising for the detection of virus N genes. Prof Mo YANG, Associate Head and Professor of Biomedical Engineering, and Dr Siu Hong Dexter WONG, Research Assistant Professor of Biomedical Engineering, employed SERS for the detection of the N gene in SARs-CoV-2.

    Together, the professors have developed a magnetic-responsive substrate consisting of heteoronanostructures, which controls the coupling distance for ultrasensitive and highly selective detection of the N gene of SARS-CoV-2.The platform magnetically modulates interparticle coupling for enhanced electric field strength and Raman signals.

    The study proves the manipulation of DNA flexibility to control the coupling distance of metallic NPs by magnetic modulation. It also provides a promising strategy for detecting long-chain viral nucleic acids such as SARS-CoV-2 genes.

    The department’s professors successfully published their findings in the international journal, ACS Applied Material Interfaces.

    To learn more: https://pubs.acs.org/doi/10.1021/acsami.1c21173
    URLhttps://www.polyu.edu.hk/feng/publications/vibrant/issue-3/research-highlights/#collapse-1
    PersonsSiu Hong Wong, Mo Yang