Myopia is thought to arise, at least in part, from altered retinal signaling, yet the biophysical mechanisms underlying this process remain poorly understood. Here, we investigate how the myopic mouse retina encodes focused and defocused images at the level of identified retinal circuits. We find that the myopic retina encodes visual information differently from the normal retina, and that lateral inhibitory networks play a critical role in detecting defocus and potentially driving myopia development. Using myopia as an example, we will discuss how retinal circuits—an integral part of the central nervous system—provide a uniquely accessible window into fundamental principles of neural computation.
Period
25 Mar 2026
Held at
Research Institute for Artificial Intelligence of Things